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Folic acid, a vital B vitamin, plays a crucial role in cell growth and DNA formation. Ensuring you get enough through supplementation is essential, especially for pregnant women and individuals with certain health conditions. Choosing a high-quality supplement tailored to your needs can significantly impact your overall well-being.
Nervous system support supplement: contains one 250 count bottle of Nature Made Folic Acid 400 mcg (665 mcg DFE) Tablets for a 250-day supply
This Folic Acid supplement contains an important B Vitamin for women of childbearing age and pregnant women
These Folic Acid supplements support nervous system function and play a critical role in the proper development of the baby's nervous system during pregnancy
Adults take one Folic Acid tablet daily with water and a meal; Folic Acid is one of the important prenatal vitamins for women before and during pregnancy
Folic Acid for women and men: These gluten-free tablets have no color added, no artificial flavors and no preservatives
United States Pharmacopeia (USP) Verified, Number 1 Pharmacist Recommended Vitamin & Supplement Brand*
These statements have not been evaluated by the Food & Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease
“This product is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”
HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is...
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
Trusted: Thorne is trusted by 100+ professional sports teams and the #1 most recommended clinical brand by consumers and health-care practitioners (Based on a 2026 independent survey of US supplement consumers and health-care practitioners)
Protein Utilization: Folic Acid functions with vitamin B12 and ascorbic acid in the breakdown and utilization of proteins*
Fetal Health: Folic acid is essential for healthy fetal neural development*
Cellular Health: Folic Acid provides optimal nutritional support for the utilization of proteins and for healthy blood cells*
Pure Quality: Our supplements are made with premium ingredients sourced from trusted suppliers and guided by nutritional experts, then manufactured and tested to verify potency and purity
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is...
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
CO-ENZYME B VITAMIN/1,000 mg TABLETS: Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.
METABOLICALLY ACTIVE FOLATE/SUPERIOR BIOAVAILABLITY: Quatrefolic is a patented form of methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources.
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
Packaged in the USA by a family owned and operated company since 1968
SUPPORTS HEALTHY HOMOCYSTEINE METABOLISM*: Folic acid is a very important member of the B-vitamin family required for DNA synthesis and genetic repair, making an adequate supply essential for rapidly dividing cells, such as red blood cells*
SUGGESTED USAGE: Take 1 tablet daily with a meal
MEMBER OF B-VITAMIN FAMILY: Folic acid is also necessary for the synthesis of methionine from homocysteine and can help to contribute to the healthy function of both the cardiovascular and nervous system*
GMP Quality Assured: A-rated, third-party certification means that every aspect of the NOW manufacturing process has been examined. Our in-house laboratories are ISO/IEC accredited for laboratory testing including for stability, potency and product...
Founded in 1968 by Elwood Richard, NOW is one of the largest independent, family- and employee-owned manufacturers of natural products
Last update on 2026-07-18 / Affiliate links / Images from Amazon Product Advertising API
How to Choose the Best Vitamin B9 (Folic Acid) Supplements
Forms of Folic Acid
There are several forms of vitamin B9 available in supplements. The most common is synthetic folic acid, which is often used in fortified foods and standard supplements. However, some individuals may have difficulty converting this form into its active state. Folate, specifically L-methylfolate (5-MTHF), is the biologically active form that the body can use directly, making it a preferred choice for many. Consider your body's absorption capabilities and any genetic predispositions when selecting a form.
Dosage and Potency
The recommended daily allowance (RDA) for folic acid varies by age and life stage. For most adults, it's 400 mcg DFE (Dietary Folate Equivalents). Pregnant women or those planning pregnancy often need higher amounts, typically 600 mcg DFE. Supplements come in various potencies, so check the label carefully to ensure it meets your specific needs without exceeding safe upper limits. Consulting a healthcare provider is advisable to determine the appropriate dosage for you.
Third-Party Testing and Purity
When selecting a vitamin B9 supplement, look for products that have undergone third-party testing. Organizations like USP, NSF International, or ConsumerLab.com verify the purity, potency, and safety of supplements. This testing ensures that the product contains what it claims and is free from harmful contaminants. A commitment to quality and transparency in manufacturing practices is a good indicator of a reliable brand.
Additional Ingredients
Some supplements may include other B vitamins or complementary nutrients alongside folic acid. While certain combinations can be beneficial, be mindful of the overall ingredient list. Ensure there are no unnecessary fillers, artificial colors, or allergens that you wish to avoid. If you have specific dietary restrictions or sensitivities, always review the full ingredient profile.
Frequently Asked Questions
Who should take a folic acid supplement?
Folic acid supplements are particularly recommended for women of childbearing age to prevent neural tube defects in pregnancy. They can also benefit individuals with folate deficiencies, certain medical conditions, or those taking medications that interfere with folate absorption. It's best to consult a doctor to determine if supplementation is right for you.
What is the difference between folic acid and folate?
Folic acid is the synthetic form found in supplements and fortified foods, while folate is the naturally occurring form found in foods like leafy greens and legumes. The body must convert folic acid into folate to use it, a process that can be inefficient for some people. L-methylfolate is the active form of folate that the body can utilize directly.
How much folic acid should I take daily?
The general recommendation for adults is 400 mcg DFE (Dietary Folate Equivalents) per day. Pregnant women or those planning pregnancy typically need 600 mcg DFE, and breastfeeding women may need 500 mcg DFE. However, individual needs can vary, so it's crucial to consult with a healthcare professional for personalized advice.
Can I take too much folic acid?
While folic acid is water-soluble and excess amounts are usually excreted, very high doses can mask a vitamin B12 deficiency. This masking can lead to irreversible neurological damage if the B12 deficiency goes untreated. It's important to adhere to recommended dosages and consult a healthcare provider if considering high-dose supplementation.
What are the signs of a folic acid deficiency?
Symptoms of folic acid deficiency can include fatigue, weakness, irritability, and shortness of breath due to megaloblastic anemia. Other signs may involve changes in skin, hair, or nail color, mouth sores, and digestive issues. A deficiency can also increase the risk of certain birth defects if it occurs during pregnancy.
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